Clinical Applications

• Helps Maintain a Healthy Intestinal Microecology*
• Supports the Natural Immune Response*
• Supports Bowel Regularity*
• Supports Lactose Digestion*

Dr. Q’s Probiotic Daily MAXIMUM STRENGTH is a vegetarian, dairy- and gluten-free, four-strain probiotic totaling 100 billion CFU† per capsule. Each vegetarian capsule is sealed in nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics such as heat, moisture, and oxygen. Dr. Q’s Probiotic Daily MAXIMUM STRENGTH provides four researched strains of beneficial bacteria, including the extensively studied HN019 strain of Bifidobacterium lactis. These live microorganisms have proven health benefits and well- established safety, and have been tested for epithelial cell adhesion and/or resistance to low pH.* To further support resistance to low pH and the delivery of microorganisms to the small intestines, Dr. Q Vitamins employs DRcaps TM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid and ensure more targeted release.*

Discussion

Supplementation with probiotics has many mechanisms of action that benefit health, including but not limited to: (1) supporting metabolic activity, such as the production of short-chain fatty acids and vitamins, nutrient absorption, and digestion of lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy balance of organisms in the intestinal tract; (3) helping to establish populations of good bacteria after disruption in balance; (4) supporting immune function; (5) promoting intestinal epithelial cell survival; (6) supporting healthy bowel function; and (7) degrading oxalates.* [1-8]

Common challenges associated with probiotic supplementation are maintaining stability of the organisms during distribution and shelf life and, once taken by a consumer, survival of the organisms as they travel through the digestive tract so that they reach the target tissue (intestines) alive. To help ensure stability, Dr. Q Vitamins packages the Dr. Q’s Probiotic Daily MAXIMUM STRENGTH capsules in sealed, nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics, such as heat, moisture, and oxygen. Careful selection of organisms is another way Dr. Q Vitamins helps ensure stability. Careful organism selection, as performed for Dr. Q’s Probiotic Daily MAXIMUM STRENGTH, is also a critical aspect of supporting digestive survival. To further support resistance to low pH and the delivery of microorganisms to the small intestines, Dr. Q Vitamins employs DRcaps TM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid to promote a more targeted release.*

HOWARU TM (Bifidobacterium lactis HN019) Discovered in 1899, B lactis play a key role in the human microflora throughout a person’s life. Researchers have identified strain HN019 as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate. [6] B lactis HN019 has been extensively studied, and its safety and effectiveness is well accepted. [7,8] To assess the impact of Bifidobacterium lactis HN019 supplementation on whole-gut transit time in adults, 100 subjects were given daily doses for 14 days of 17.2 billion colony-forming units (CFU), 1.8 billion CFU, or placebo. Decreases in mean whole-gut transit time over the 14-day study period were statistically significant in the high-dose group and the low-dose group, but not in the placebo group. [8] This level of dosing also supported other parameters of healthy GI function, as were self-reported by patient survey. [8] In another study of preschool-age children, supplementing milk for one year with 1.9 x 10 CFU per day B lactis HN019 and 2.4 g/day of prebiotic oligosaccharides supported both healthy iron status and weight gain. [9] In a randomized, double-blind, placebo-controlled human dietary intervention study in elderly subjects (>60 yrs.), supplementary B lactis HN019 resulted in statistically significant increases in the beneficial organisms bifidobacteria and lactobacilli.* [10]

Lactobacillus acidophilus (Lactobacillus acidophilus La-14) This common inhabitant of the human mouth, intestinal tract, and vagina, is also found in some traditional fermented milks (e.g., kefir) and is widely used in probiotic foods and supplements. It has a history of safe human consumption. The L acidophilus La-14 strain is of human origin and has been identified as a type A1 L acidophilus. L acidophilus shows excellent adhesion to human epithelial cell-lines.* [11,12]

Lactobacillus plantarum (Lactobacillus plantarum Lp-115) This bacteria was isolated from plant material and is abundantly present in lactic acid-fermented foods, such as olives and sauerkraut. In vitro studies have shown that L plantarum strain Lp-115 has excellent adhesion to epithelial cell lines. [13] In addition, L plantarum is resistant to low pH conditions and survives the presence of bile at duodenal concentrations.* [13,14]

Bifidobacterium longum (Bifidobacterium longum Bl-05) The B longum Bl-05 strain is well accepted as safe for human consumption. B longum is resistant to low pH and bile salts and is well suited to the intestinal environment.*

Directions
Take one capsule with water daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Does Not Contain
Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

• Helps Maintain a Healthy Intestinal Microecology*
• Supports the Natural Immune Response*
• Supports Bowel Regularity*
• Supports Lactose Digestion*

Dr. Q’s Probiotic Daily is a vegetarian, dairy- and gluten-free, four-strain probiotic totaling 30 billion CFU† per capsule. Each vegetarian capsule is sealed in nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics such as heat, moisture, and oxygen. Dr. Q’s Probiotic Daily provides four researched strains of beneficial bacteria, including the extensively studied HN019 strain of Bifidobacterium lactis. These live microorganisms have proven health benefits and well-established safety, and have been tested for epithelial cell adhesion and/or resistance to low pH.*

To further support resistance to low pH and the delivery of microorganisms to the small intestines, Dr. Q Vitamins employs DRcaps TM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid and ensure more targeted release.*

Discussion

Supplementation with probiotics has many mechanisms of action that benefit health, including but not limited to: (1) supporting metabolic activity, such as the production of short-chain fatty acids and vitamins, nutrient absorption, and digestion of lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy balance of organisms in the intestinal tract; (3) helping to establish populations of good bacteria after disruption in balance; (4) supporting immune function; (5) promoting intestinal epithelial cell survival; (6) supporting healthy bowel function; and (7) degrading oxalates.*

Common challenges associated with probiotic supplementation are maintaining stability of the organisms during distribution and shelf life and, once taken by a consumer, survival of the organisms as they travel through the digestive tract so that they reach the target tissue (intestines) alive. To help ensure stability, Dr. Q Vitamins packages the Dr. Q’s Probiotic Daily capsules in sealed, nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics, such as heat, moisture, and oxygen. Careful selection of organisms is another way Dr. Q Vitamins helps ensure stability. Careful organism selection, as performed for Dr. Q’s Probiotic Daily, is also a critical aspect of supporting digestive survival. To further support resistance to low pH and the delivery of microorganisms to the small intestines, Dr. Q Vitamins employs DRcaps TM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid to promote a more targeted release.*

HOWARU TM (Bifidobacterium lactis HN019) Discovered in 1899, B lactis play a key role in the human microflora throughout a person’s life. Researchers have identified strain HN019 as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate. [6] B lactis HN019 has been extensively studied, and its safety and effectiveness is well accepted. [7,8] To assess the impact of Bifidobacterium lactis HN019 supplementation on whole-gut transit time in adults, 100 subjects were given daily doses for 14 days of 17.2 billion colony-forming units (CFU), 1.8 billion CFU, or placebo. Decreases in mean whole-gut transit time over the 14-day study period were statistically significant in the high-dose group and the low-dose group, but not in the placebo group. [8] This level of dosing also supported other parameters of healthy GI function, as were self-reported by patient survey. [8] In another study of preschool-age children, supplementing milk for one year with 1.9 x 10 CFU per day B lactis HN019 and 2.4 g/day of prebiotic oligosaccharides supported both healthy iron status and weight gain. [9] In a randomized, double-blind, placebo-controlled human dietary intervention study in elderly subjects (>60 yrs.), supplementary B lactis HN019 resulted in statistically significant increases in the beneficial organisms bifidobacteria and lactobacilli.* [10]

Lactobacillus acidophilus (Lactobacillus acidophilus La-14) This common inhabitant of the human mouth, intestinal tract, and vagina, is also found in some traditional fermented milks (e.g., kefir) and is widely used in probiotic foods and supplements. It has a history of safe human consumption. The L acidophilus La-14 strain is of human origin and has been identified as a type A1 L acidophilus. L acidophilus shows excellent adhesion to human epithelial cell-lines.* [11,12]

Lactobacillus plantarum (Lactobacillus plantarum Lp-115) This bacteria was isolated from plant material and is abundantly present in lactic acid-fermented foods, such as olives and sauerkraut. In vitro studies have shown that L plantarum strain Lp-115 has excellent adhesion to epithelial cell lines. [13] In addition, L plantarum is resistant to low pH conditions and survives the presence of bile at duodenal concentrations.* [13,14]

Bifidobacterium longum (Bifidobacterium longum Bl-05) The B longum Bl-05 strain is well accepted as safe for human consumption. B longum is resistant to low pH and bile salts and is well suited to the intestinal environment.* [14]

Directions
Take one capsule with water daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Does Not Contain
Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives

• Supports Healthy Weight Management*
• Promotes Gut Barrier Function*
• Promotes Intake of Less Calories*
• Supports Reduction of Body Fat Mass*

At the turn of the 20th century, Nobel Prize laureate Ilya Metchnikov introduced the concept that bacteria in yogurt can support the neutralization of gut pathogens, which may, in turn, support longevity. Since then, the role of beneficial bacteria in human health has become well established in the literature and continues to evolve. In 2002, the FAO (Food and Agriculture Organization of the United Nations) and WHO (World Health Organization) working group experts established a definition of probiotics as “live strains of strictly selected microorganisms, which, when administered in adequate amounts, confer a health benefit on the host.” Results of clinical studies have suggested a positive effect of supplemental probiotics on a wide range of health concerns, including gastrointestinal issues, allergies, immune support, and weight-management.*[1-7] Epithelial integrity is key to the function of the gastrointestinal tract, and according to in vitro and animal research, disturbance of this integrity appears to be linked to metabolic disorders. To address the potential effects of consuming specific probiotic bacteria to protect epithelial cells from the effects of pathogenic bacteria, Caco-2 cells were treated with cell-free supernatants (CFSs) of four probiotics— Bifidobacterium lactis‡ 420 (B420), Bifidobacterium lactis HN019, Lactobacillus acidophilus NCFM, and Lactobacillus salivarius Ls-33— and by a cell-free supernatant of a pathogenic bacteria Escherichia coli (EHEC) O157:H7. Tight junction integrity, as well as expression of cyclooxygenases, were measured with results suggesting that the B420 CFS counteracted the damage done by the EHEC CFS.[8] One cannot be certain that B420 CFS would prevent junction damage by live bacteria EHEC, but the results suggest that probiotic bacteria produce soluble metabolites that appear to protect epithelial cells and positively influence cytokine balance. Awareness of the existence and activity of soluble bacterial metabolites in vitro leads to speculation whether the same metabolites are also formed in the intestine with similar effects in vivo. However, the evidence presented does seem to suggest that oral consumption of B420 probiotic may benefit epithelial integrity.* In animal research, the potential benefit of B420 in reducing high-fat, diet-induced body weight gain and diabetes was studied with results indicating a reduction of fat mass and glucose intolerance in both obese and diabetic mice. Reduced intestinal mucosal adherence and decreased levels of plasma lipopolysaccharide suggested a mechanism related to reduced translocation of gut microbes.*[9] HOWARU® Shape B420 (Bifidobacterium animalis subsp lactis B420) The in vitro and experimental animal studies discussed above-utilized B420 with positive results in improving epithelial integrity and potential for a role in weight management. These results led to the need for a human trial to validate these effects. In a double-blind, placebocontrolled study in overweight volunteers (N = 225) aged 18-65, the effects of B420 and the combination of B420 with a prebiotic fiber on body-fat mass and other weight-related parameters were investigated. The authors speculated that the underlying mechanism for reduction of body fat mass could have been related to circulating zonulin (a potential marker of gut barrier function) and C-reactive protein (CRP), speculation that had been supported by previous findings with experimental animals. Subjects were not required to make changes in dietary or exercise habits. Body composition was monitored with dual-energy X-ray absorptiometry, and the primary outcome was a relative change in body fat mass when treatment groups were compared to placebo. Other outcomes included anthropometric measurements, food intake, and blood and fecal biomarkers. Although results indicated that B420 in combination with the prebiotic offered the most significant benefits when compared to placebo (4.5% reduction in body fat mass), B420 alone (1010 CFU/day) resulted in reduced body fat mass of 4.0% with changes in fat mass being most pronounced in the abdominal region and in waist circumference. Significantly reduced caloric intake was also shown in both groups compared to placebo, and there were no differences between groups in the incidence of adverse events.*[7] Building on the data reported for B420 thus far, investigators looked into whether changes in the gut microbiota were associated with clinical benefits and obesity-related issues. Fecal and plasma samples obtained from a subset (n = 134) of the participants in the above mentioned clinical trial were assessed at baseline, two, four, and six months as well as one-month post-intervention. Consumption of B420 resulted in alterations of the specific gut microbiota Lactobacillus and Akkermansia muciniphila. Akkermansia muciniphila, often in lower amounts in obese individuals with metabolic dysfunction, is associated with improved metabolic health. This strain supports gut barrier function and improves obesity-related markers and thus supports the probiotic benefits of B420.[10] More clinical trials are warranted to confirm these effects in larger participant populations and to further elucidate the underlying mechanisms.*

Clinical Applications

• Supports a Healthy Microbiome*
• Replenishes Good Bacteria in the Gut*
• Supports the Natural Immune Response*
• Supports Lactose Digestion*
• Supports Bowel Regularity*

Probiotic Ultra Max 350 Billion features a diverse blend of HOWARU® and FloraFIT ® probiotic strains to support a healthy gut microbiome. Each strain is well-researched and identity-verified and has been genetically characterized and properly classified for your safety and assurance. These strains were not only selected for their health benefits and complementary actions but also for their viability and stability. To protect the bacteria from light and moisture, each flavoring- and sweetener-free serving of Probiotic Ultra Max 350 Billion comes in an opaque, foil-lined stick pack.*

Discussion

Multiplicity of microbiota species is characteristic of the GI microbiome in healthy individuals, and a loss in species has adverse effects.Dietary diversity and taking a variety of probiotic species and strains are methods that help support a healthy microbiome.[1,4] Probiotic Ultra Max 350 Billion provides 18 different strains belonging to 13 different species of three different genera. The HOWARU and FloraFIT strains that comprise this formula are stable, proven, and trusted worldwide.*

Featured Strains: Bifidobacterium lactis HN019 and Lactobacillus rhamnosus HN001

B lactis HN019 and L rhamnosus HN001 have been studied extensively in vitro and in vivo (in animals and humans) to establish beneficial effects and safety.[5-20] In human research, B lactis HN019 significantly decreased mean whole-gut transit time in adults compared to placebo.[8] Supplementation also had a positive effect on functional GI symptoms, as were self-reported by patient surveys. In a randomized, double-blind, placebo-controlled human dietary intervention study in subjects 60 or more years of age, supplementary HN019 resulted in desirable changes in the intestinal microflora, including significant increases in bifidobacteria and lactobacilli.[13] HN019 has also shown promising effects on parameters of cardiovascular and metabolic health. Compared with baseline and control group values, individuals taking 27 billion CFU had a significant reduction in body mass index, significant improvements in cholesterol and low-density lipoprotein metabolism, and significant decreases in tumor necrosis factor-alpha and interleukin-6.[19] In a three-week study, individuals consuming low-fat/low-lactose milk supplemented with HN019 or HN001 showed increased immune activity when compared to a milk-alone run in.[10] These increases were significantly correlated with age; that is, subjects older than 70 years experienced significantly greater improvements than those under 70 years. Researchers suggest that these results demonstrate the ability of HN019 and HN001 to combat some of the deleterious effects of immunosenescence on cellular immunity.[10] Animal studies demonstrate the ability of HN001 to support natural and acquired immunity as well as promote resistance.[17,18] More recently, human studies have demonstrated HN001’s protective effect on skin health in genetically susceptible individuals.*[7,11]

Other Strains in Probiotic Ultra Max 350 Billion Have Demonstrated Probiotic Effects in Either In Vitro or In Vivo Research:

• Cause the development of inhibition zones around Clostridium difficile, Salmonella typhimurium, Staphylococcus aureus, Escherichia coli, and Listeria monocytogenes in agar assays*[20]
• Populate vaginal tissue*[21]
• Induce moderate maturation and activation of dendritic cells*[22]
• Degrade oxalates*[23]
• Increase IgA and IgG responses*[25]
• Reduce levels of E coli and enterococcus after antibiotic therapy*[26]
• Help increase and recover numbers of intestinal lactobacilli and/or bifidobacteria*[27]
• Promote well-being in relation to intestinal cytokine production*[28,29]
• Improve gastrointestinal health and well-being when under challenge*[27,29]
• Help maintain upper respiratory health*[30]
• Alter the fecal microbiota in obese subjects*[31]
• Maintain healthy fluid balance and integrity of intestinal wall*[32]
• Support intestinal barrier function*[32]

Genetic Testing, Acid and Bile Tolerance, Adhesion

Each of the lactic acid-producing strains in Probiotic Ultra Max 350 Billion has a history of safe consumption and, based on testing,

is regarded to have excellent probiotic potential.[20,33,34] Each bacterium has been genetically characterized and properly classified by

independent labs. The organisms have demonstrated tolerance to low pH conditions (hydrochloric acid and pepsin at pH3 for one hour at 37°C), tolerance to bile at concentrations existing in the duodenum, and the ability to adhere to human epithelial cell lines (Caco-2 and HT-29). Adhesion is thought to be an important factor affecting these bacteria’s length of time in the intestines, their ability to modulate immune function, and their ability to take up intestinal “real estate” in competition with other organisms.*[34]

Many of the strains have had additional studies performed, which include testing for the following[20]:

Competitive Inhibition – The ability of probiotics to maintain a healthy microbial balance in the gut is unquestionably important to its usefulness. Probiotics produce inhibitory compounds that limit the growth of other organisms, they compete with other organisms for adhesion sites and nutrients, and they inhibit the production of toxins, among other actions.*

Cytokine and Immune Modulation – Microbiota are key elements in the body’s defense system. Cytokines regulate immune system function, and the ability of many of the strains in Probiotic Ultra Max 350 Billion to upregulate or downregulate various cytokines has been demonstrated.*

Antibiotic Resistance – Antibiotic susceptibility patterns are an important means of indicating the potential of an organism to be readily inactivated by antibiotics used in human therapy. Importantly, acquired antibiotic resistance or antibiotic resistance transfer have not been detected in any of these strains.*

Directions

Dissolve the contents of one stick pack (350 billion CFUs‡)†† into 1-2 oz of pure water and consume once daily, or take as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Does Not Contain

Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives

• Gastrointestinal Support
• Enhanced Production of Short Chain Fatty Acids

Dr Q’s Renew features four specialized ingredients for enhanced gastrointestinal support. This unique formula contains concentrated extract of licorice that has been processed to remove glycyrrhizin—thus reducing risk of side effects associated with licorice. Glutamine serves as the predominant fuel and nitrogen source for the mucosal lining of the gastrointestinal (GI) tract. Arabinogalactan from the North American larch tree is a naturally occurring polysaccharide that provides excellent support for GI health. Research suggests that arabinogalactan plays a role in the promotion of gut microflora and may increase beneficial short-chain fatty acid production. The Aloe vera leaf extract in Dr Q’s Renew has been processed to remove the bitter principles and prevent a laxative effect.

Discussion

L-Glutamine, the most abundant free form amino acid in the body, is very important for maintaining gastrointestinal and stimulated immune cell functioning. It is an important transporter of nitrogen (and carbon) in the body and therefore, is vital in wound healing. Although glutamine can be synthesized by the intestinal mucosa, during periods of physiological stress when needs can not likely be met by the body alone, gut epithelial atrophy, ulceration and even necrosis are possible. [1] L-glutamine is metabolized to ammonia and glutamate.

Arabinogalactan, a polysaccharide derived from the Larch tree, contributes fermentable fiber to this formula in addition to having immuno-stimulatory properties. It minimizes ammonia synthesis and absorption, enhances production of short chain fatty acids and increases the gut microflora population.

Licorice Root Extract 10:1(deglycyrrhized) is a concentrated extract that has been processed to remove glycyrrhizin, thus eliminating any risk of licorice-associated side effects. It is anti-inflammatory, antispasmotic and has laxative and soothing effects. Aspirin-induced mucosal damage has been shown to be reduced by administration of deglycyrrhized licorice.

Aloe Leaf Extract (standardized to 50% polysaccharides), used for thousands of years, is perhaps most well-known for healing of damaged epithelial tissue, including the bowel lining. Despite the lack of scientific published studies there is anecdotal evidence to suggest that aloe vera helps inflammatory conditions of the gastrointestinal tract. In some individuals it may increase G.I. transit time, improve protein digestion and absorption, increase stool bulk and normalize stool bacteria where high levels of yeasts previously existed. [4] The aloe extract used in Dr Q’s Renew does not have a laxative effect because the bitter principles have been removed.

Directions

Mix one scoop in 2-4 oz water one to three times daily, or as directed by your healthcare practitioner. Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Does Not Contain

Wheat, gluten, corn protein, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.

Clinical Applications

• Supports Natural Detoxification Mechanisms*
• Supports Gastrointestinal Health*
• Supports a Balanced Cytokine Profile*
• Lactose-Free Vegan Protein*

Ultra Detox Gastrointestinal Hepatic Inflammatory Formula is a comprehensive, fructose-free, low-allergy– potential dietary supplement designed to support gastrointestinal (GI) function and balanced detoxification. It features Vegan Protein Blend, Dr. Q’s Vitamins’s proprietary amino acid and pea/rice protein blend; Aminogen®, to facilitate protein absorption; phytonutrients; mineral amino acid chelates; and activated B vitamins, including Quatrefolic®† and methylcobalamin. In conjunction with a modified elimination diet, Ultra Detox Gastrointestinal Hepatic Inflammatory Formula addresses GI and hepatic function as well as eicosanoid balance and cytokine metabolism. This formula is suitable for vegans.*

Ultra Detox Gastrointestinal Hepatic Inflammatory Formula contains macro- and micronutrients, as well as a host of ingredients (some patented or proprietary) that support fatty acid metabolism, gastrointestinal health, and healthy eicosanoid and cytokine metabolism. Activated cofactors support mitochondrial energy production needed for biotransformation and detoxification. This formula’s ingredients help moderate phase I detoxification, upregulate and support phase II pathways, and provide antioxidant support as well.*

Protein Metabolism

Vegan Protein Blend is Dr. Q’s Vitamins’s proprietary blend of pea protein isolate and rice protein concentrate, L-glutamine, glycine, and taurine. Generation of glutathione and sulfation cofactors—vital for phase II conjugation—requires an array of amino acids. The combination of pea protein and rice protein, containing a complement of amino acids, achieves an amino acid score of 100%. Glutamine, a conditionally essential and versatile amino acid with two nitrogen moieties, is crucial to nitrogen metabolism and helps maintain healthy liver tissue and function.[1,2] The amino acid glycine is needed for bile synthesis, phase II detoxification, and glutathione production. Taurine, a derivative of the sulfur-containing amino acid cysteine, is also important for synthesis of bile salts and helps stabilize cell membranes.*

Gastrointestinal Support

Ginger root, included to support healthy digestion including the release of bile from the gallbladder, acts at several sites to moderate PGE(2) production and support the normal response to inflammation.[3] Fiber (from inulin and flaxseeds) supports production of short-chain fatty acids as well as a healthy intestinal flora. MeadowPure, an organic flaxseed complex, possesses excellent oxidative stability, supports antioxidant activity, and provides lignins, soluble fiber, and omega-3 and omega-6 essential fatty acids.[4] Glutamine plays a key role in healthy intestinal cell proliferation and gut barrier integrity, immune function, and normal tissue healing.*[1,2]

Detoxification Support

Ellagic acid (from pomegranate extract) prevents over-induction of CYP1A enzymes, works at the gene level to induce synthesis of glutathione-S-transferases and other phase II activities, binds directly to toxins, and protects DNA and hepatocytes.[5,6] Watercress is a rich source of beta-phenylethyl isothiocyanate (PEITC)—a versatile compound found to inhibit phase I enzymes and induce the phase II enzymes associated with biotransformation and excretion of toxins. Watercress was found to contain even stronger phase II inducers known as 7-methylsulfinyheptyl and 8-methylsulfinyloctyl isothiocyanates as well.[7,8] Green tea catechins not only support antioxidant activity but also appear to act as modulators of phase I and phase II detoxification.[9] Choline is present to support lipid metabolism in the liver and can be converted to betaine, a methyl donor.*[10]

The active, bioavailable form of B vitamins (pyridoxal-5’-phosphate (B6), 5-methyltetrahydrofolate (folate), methylcobalamin (B12)) and glycine all support amino acid conjugation and are vital for the detoxification of xenobiotics and xenoestrogens. 5-methyltetrahydrofolate (5-MTHF), methylcobalamin, betaine, and methylsulfonylmethane (MSM) are present to support methylation and detoxification. 5-MTHF supports healthy folate nutrition, especially in those with variations in folate metabolism. In Ultra Detox Gastrointestinal Hepatic Inflammatory Formula, 5-MTHF is provided as Quatrefolic® for enhanced stability, solubility, and bioavailability.*[11]

Preventium®, a patented form of potassium hydrogen d-glucarate, supports glucuronidation. Sulfation is supported by MSM and sodium sulfate. Acetylation is supported by d-calcium pantothenate, pyridoxal-5’-phosphate, and magnesium. Several minerals in Ultra Detox Gastrointestinal Hepatic Inflammatory Formula are provided as Albion® mineral chelates and TRAACS® mineral amino acid chelates for enhanced gastrointestinal absorption and bioavailability.*[12]

Antioxidant Support and Cytokine Balance

Bioflavonoids, quercetin, rutin, and curcumin support antioxidant activity, counter free radicals, and support healthy eicosanoid and cytokine metabolism.[13,14] Curcumin has a long history of use for its support of a normal, healthy response to inflammation.[15] N-acetyl-cysteine (NAC) stimulates glutathione synthesis, enhances glutathione-S-transferase activity, and promotes detoxification.[16] Selenium glycinate provides support for glutathione metabolism and antioxidant protection.*

Ultra Detox Gastrointestinal Hepatic Inflammatory Formula provides an array of nutrients that supports gastrointestinal health; detoxification and antioxidant mechanisms; and a normal, healthy response to inflammation and cytokine balance. This formula is designed to be used as part of a step-approach cleanse in conjunction with a modified elimination plan.*

Directions

Blend, shake, or briskly stir 2 level scoops (58 g) into 10-12 ounces chilled, pure water (or mix amount for desired thickness) and consume once daily, or use as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Does Not Contain

Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

• Supports Healthy Microbial Balance
• Provides Nutrients That Support Antioxidant Activity
• Supports Gastrointestinal Health

Discussion
Dr Q’s YeastMycin offers a functional approach to achieving and maintaining balance in gastrointestinal flora, a primary component of GI health. [1] The complementary blend of ingredients is formulated to support antioxidant activity, microbial balance, and gastrointestinal function.

Origanox TM† WS The water-soluble form of Origanox (Origanox WS) is a natural plant extract from the edible herb Origanum vulgare (oregano). Essential oils and phytonutrients from oregano, including rosmarinic acid and quercetin, have been studied closely for their role in supporting antioxidant mechanisms and healthy microbial balance in the body. [2,3] The ORAC (oxygen radical absorbance capacity) value of Origanox is 5,800 units per gram. [4] The ORAC scale, developed by scientists at the National Institute of Aging, is a measure of the scavenging capacity of antioxidants against free radicals that cause oxidative stress.

Sodium Caprylate, a derivative of caprylic acid, is a medium-chain fatty acid with a long research history. Research indicates that it has the potential to support healthy microbial balance in the intestines without adversely affecting beneficial GI flora. Studies also suggest that it may have direct effects on cellular integrity and growth, further supporting gastrointestinal health.

Ginger (Zingiber officinale) plays an important role in Dr Q’s YeastMycin, offering support for gastrointestinal, immune, and antioxidant systems. [7-9] Ginger has been used for centuries for support of normal gastric function and activity.

Turmeric Extract Turmeric (Curcuma longa) has been used historically to support normal muscular contraction/relaxation and digestion. This ancient herb is rich in curcumin, which has been researched considerably for its protective effects, [10,11] as well as its ability to support healthy cytokine balance. [12,13] The addition of turmeric to Dr Q’s YeastMycin provides additional support for GI function and balance.

Olive Leaf Extract from the traditional medicinal plant Olea europaea is known for its array of healthful attributes, including support for immune and antioxidant activities. While studying the attributes of olive leaf, scientists in the late 19th century isolated oleuropein, [14] which is converted in the body to the active component elenolic acid. By the late 1960s, research focused on the role of both oleuropein and elenolic acid. Oleuropein and rutin in olive leaf may contribute to maintaining healthy gastrointestinal microflora. [15] Olive leaf extract in Dr Q’s YeastMycin is standardized to 20% oleuropein, while less concentrated formulas are standardized to as little as 6% oleuropein.

Dr Q’s YeastMycin is a comprehensive formula designed to support GI tract health and microflora balance while concurrently supporting antioxidant systems and tissue health.

Directions
Take one to two capsules, one to two times daily, or as directed by your healthcare practitioner. Do not use if tamper seal is damaged. Children, pregnant or lactating women, and individuals receiving cancer treatment or taking an anticoagulant should consult their healthcare practitioner prior to use.

• Supports Healthy Microbial Activity in the GI Tract
• Supports Healthy Immune Function
• Promotes GI Mucous Membrane Health
• Stimulates Circulation

​
Discussion
Many plants have been used throughout history for their ability to influence microbial activity and support healthy immune function. Potency is an important aspect in achieving the benefits imparted by an herbal supplement. The herbs in Dr. Q’s CandibacteMycn are concentrated to a 4:1 end ratio. This means that the equivalent raw herb conversion is 4 kg raw herb to 1 kg of extracted material. All actives are provided in easy-dissolving vegetarian capsules.

Berberis aquifolium (Oregon grape) Berberine is a plant alkaloid derived from a variety of herbs, including Oregon grape
root. This phytochemical constituent has a long history of use in Chinese and Ayurvedic medicine owing to its effectiveness and safety. Berberine extracts have demonstrated significant ability to influence the activity of a variety of organisms that affect human health. [1-3] Mechanisms of action may include effects on organism adhesion and intracellular invasion, metabolic activity, maturation, and enterotoxin formation. [1,4] Berberine can also address the intestinal secretion of water and electrolytes induced by certain organism toxins, thereby supporting healthy stool formation. [1] Furthermore, it may reduce smooth muscle contraction and intestinal motility, and delay intestinal transit time. Both in vitro and animal research suggest that berberine can affect COX-2 protein.

Myrica cerifera (bayberry) The root bark and berry of bayberry have been traditionally used as an astringent and circulatory stimulant. Like the berry, the root bark contains tannin constituents that are responsible for its astringent action. [5,6] Astringent herbs are traditionally used to maintain the already normal release or secretion of perspiration, stool, essence (the body’s reproductive and regenerative substance), and urine. As a circulatory stimulant, bayberry helps to increase body energy levels and supports toxin elimination. Myricitin, a flavonoid isolated from bayberry, exhibits antioxidant activity, particularly in the colon.

Citrus x paradisi (grapefruit) The seed extract of grapefruit, commonly known as GSE, is widely used as an oral supplement to maintain healthy gut ecology. GSE is employed by the food processing and agricultural industries for a diversity of applications. It is important to note that GSE contains a variety of phenolic substances with antioxidant activity including vitamin C, hesperidin, limonoids, tocopherols, serols, citric acid, and other trace minerals.

Zinc The supportive effects of zinc on immunity and microbial balance are well documented. [10,11] Zinc ions are thought
to work directly in the GI tract, affecting microbial activity therein. Immune cells, due to their high rate of proliferation and differentiation, need a constant and sufficient supply of zinc. Although further study is needed, zinc supplementation also shows promise in its ability to support healthy stool formation. In this formula, zinc is provided as Albion ® TRAACS ® zinc glycinate chelate for optimal absorption and utilization.

Directions
Take one capsule daily, or as directed by your healthcare practitioner. Do not use if tamper seal is damaged.

• Supports Digestion, Assimilation, and Elimination
• Promotes Gastrointestinal Motility and Stool Bulk
• Supports Final Phases of Detoxification

Dr Q’s Colon Ease is designed to support gastrointestinal (GI) regularity and complement dietary fiber intake. Magnesium citrate is present to support muscle relaxation and bowel elimination. Cape Aloe is added to support normal GI transit time and stool bulk. Triphala, a balanced blend of astringent fruits used extensively in Ayurveda, is present to support all phases of digestion, assimilation, and elimination. Gastrointestinal regularity in turn plays a fundamental role in detoxification, providing a major route for elimination of toxins.

Discussion

Dr Q’s Colon Ease addresses an issue of universal importance: gastrointestinal (GI) health. GI regularity and function is vital to physiological balance and overall well-being. How well the body digests, assimilates, and eliminates metabolic fuel and metabolic waste determines health at the cellular level. Toxins that enter the body must be detoxified and their metabolites must exit the body. Gastrointestinal elimination plays a major role in detoxification by expelling the remnants of toxic molecules. If these harmful remnants are not eliminated, they can recirculate throughout the body.

Magnesium Magnesium citrate, the type of magnesium in Dr Q’s Colon Ease, is used for colonoscopy preparation. Chosen for its promotion of muscle relaxation and effective elimination of feces through the bowel, magnesium citrate is also highly bioavailable. [1] It should be noted that particular forms of magnesium may be absorbed differently. Please note that while magnesium citrate is best suited to support gastrointestinal elimination, the patented amino acid chelates such as the lysyl glycinate and dimagnesium malate chelates in Dr. Q Vitamins’s Magnesium Chelate formula are designed to be bioavailable and easily absorbed.

As a macromineral, magnesium supports cell, tissue, and organ function and participates in over 300 metabolic reactions in the body. This essential mineral plays a pivotal role in energy-producing reactions, detoxification, muscle and nerve function, and skeletal structure. [2,3] Magnesium can readily become depleted due to inadequate intake, poor absorption, excessive losses, and drug-induced nutrient depletions.

Cape Aloe (Aloe ferox) Cape Aloe has a long history of use in South Africa and continues to be closely studied for its valuable attributes, [4] specifically how it supports GI regularity. The herb is ideally used in the short term to support the elimination of feces and subsequently the elimination of toxins. Recent research suggests that Cape Aloe supports gastrointestinal regularity and is well tolerated. Administration of the herb in animals showed no negative toxicological effects at doses of up to 200 mg/kg body weight over a seven-day period.

Triphala Triphala comprises three sour, astringent fruits: Emblica officinalis (amla), Terminalia belerica (behada), and Terminalia chebula (harada). This tannin-rich herbal compound has been used traditionally for supporting digestion, assimilation, and elimination. [6] Triphala is considered to be a cornerstone of the art and practice of Ayurveda, and it is used throughout India in herbal products. Modern-day clinical trials have confirmed the benefits of traditional uses of triphala, especially gastrointestinal support. Researchers indicated that triphala positively supports appetite, GI health, and rejuvenation.

Dr Q’s Colon Ease is intended for short-term use only and should never be consumed during pregnancy. Follow directions and label cautions carefully.

Directions

Take one to two capsules at bedtime with 8 oz of water, or as directed by your healthcare practitioner. Do not use if tamper seal is damaged.

Does Not Contain
​
Wheat, gluten, corn protein, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.

TOTAL Digest is a full-spectrum pancreatic enzyme supplement created specifically to promote digestive health. Insufficient digestion can lead to digestive problems such as cramping and diarrhea. It can also lead to more severe problems such as high blood pressure‚ plaque in your arteries and much more. For these reasons‚ it is important to have the right amount of enzymes in your digestive system so your body can digest and absorb the nutrients it needs.

Betaine HCl is the main ingredient in Dr Q’s TOTAL Digest ; it provides hydrochloride‚ which helps break down food in your stomach. This ingredient will establish a healthy balance of stomach acid if your levels are too low. Since a deficiency in those acids hinders absorption‚ it could cause other severe health problems. As a result‚ betaine HCl helps you effectively absorb certain needed nutrients.

The Dr Q’s TOTAL Digest formula also contains the GastroENZ proprietary blend‚ which contains:

• Protease (acid protein and DPPIV) to break down protein.
• Amylase to help break down starch‚ which is naturally produced in the pancreas.
• Lipase helps break down certain fats during the digestive process‚ and is also produced by your pancreas.
• Pepsin converts proteins into amino acids during digestion.
• Ox bile extract works to digest and absorb fats.
• Lactase to digest lactose‚ which is contained in dairy products.
• Glucoamylase allows your body to use starch by converting it into glucose.
• Invertase metabolizes and digests a type of sugar known as sucrose.
• Diastase break downs carbohydrates and turns them into sugar.​